Abstract: In January 2024，some pregnant sows experienced clinical cases such as miscarriage and stillbirth in a large⁃scale pig farm in Guangdong Province. To diagnose the cause of the outbreak，blood samples from aborting sows and organs samples from stillborn fetuses were collected. Common pathogens causing miscarriage in sows，such as Porcine Circovirus 2/3（PCV2/3），Porcine Reproductive and Respiratory Syndrome Virus 2（PRRSV2），Porcine Pseudorabies Virus（PRV），Toxoplasma gondii，etc。，have been detected using fluorescence quantitative PCR methods. Then，the genotypes and subtypes of the detected pathogens were to identify via nucleic acid sequencing analysis. In addition，the bacterial pathogens were isolated and identified，and used for screening sensitive drugs to guide clinical medication. The results showed that PCV2d and Aeromonas rivipollensis are the main pathogens causing the disease of pregnant sows in this pig farm，and the latter is sensitive to penicillin，amoxicillin，cefradine，and florfenicol，indicating that these candidate drugs can be used for clinical treatment.

Key words: Porcine Circovirus subtype 2d, Aeromonas rivipollensis, Antibiotic sensitivity test

摘要： 2024年1月，广东某规模化猪场出现部分妊娠母猪流产、产死胎，为诊断发病原因，通过采集流产母猪血液、死胎脏器，应用荧光定量PCR方法检测猪圆环病毒2型/3型、猪繁殖与呼吸综合征病毒2型、猪伪狂犬病毒、弓形体等常见致母猪流产病原，并通过测序方法鉴定病原基因型及亚型；采用细菌分离鉴定方法培养细菌病原，并开展药敏试验指导临床用药。结果显示，该场流产母猪感染了猪圆环病毒2d亚型与河流漫游球菌，药敏试验显示分离的河流漫游球菌对青霉素、阿莫西林、头孢拉定、氟苯尼考均敏感。

关键词: 猪圆环病毒2型, 河流漫游球菌, 药敏试验