Abstract: Porcine epidemic diarrhea（PED），caused by the porcine epidemic diarrhea virus（PEDV），is a highly contagious and lethal infectious disease in pigs. The virus primarily targets the intestinal epithelium，leading to acute diarrhea and dehydration. Since the emergence of highly pathogenic PEDV variants in China in late 2010，PEDV has spread globally，causing significant economic losses on the global swine industry. This review systematically summarizes the current epidemiological trends，genetic variations and hazards of PEDV. Focusing on the three fundamental components of infection source，transmission route，and susceptible animal of infectious diseases，this paper highlights the challenges in current PED prevention and control，and proposes a comprehensive PED prevention and control strategy emphasizing enhanced biosecurity measures and scientifically immunization programs.

Key words: PEDV, Large?scale pig farm, Challenges in prevention and control, Comprehensive prevention and control

摘要： 猪流行性腹泻（Porcine epidemic diarrhea，PED）是由猪流行性腹泻病毒（Porcine epidemic diarrhea virus，PEDV）引起的一种以肠道损伤、严重腹泻、脱水为特征的高度致死性猪 传染病。自2010年底中国暴发高致病性PEDV变异株以来，PEDV在全球持续流行，给养猪业 造成巨大经济损失。该文综述了当前PEDV流行变异特征及其危害，从传染源、传播途径、易感 动物三个基本环节，重点阐述现有PED防控所面临的挑战，提出以加强生物安全管理和科学合 理免疫为侧重的PED综合防控策略。

关键词: 猪流行性腹泻病毒（PEDV）, 规模化养猪场, 防控挑战, 综合防控措施