Abstract: Eastern equine encephalitis（EEE）is a zoonotic disease caused by the Eastern equine encephalitis virus（EEEV） and primarily transmitted through arthropod vectors. The infection can cause severe neurological diseases and mortality in horses，humans，and other vertebrates，posing a serious threat to both the equine industry and public health. In recent years，cases of EEEV infection have been reported in multiple regions worldwide， highlighting the need for enhanced epidemic prevention and control. Although vaccination remains a key preventive strategy，no licensed vaccine is currently available. This paper reviews recent research directions and progress in EEEV vaccine development，aiming to provide references for future vaccine research and disease control efforts.

Key words: Eastern equine encephalitis virus；Zoonosis；Vaccines development；Research progress

摘要： 东方马脑炎（Eastern equine encephalitis，EEE）是由东方马脑炎病毒（Eastern equine encephalitis virus，EEEV）经虫媒传播引起的人兽共患病，可导致马、人类及其他脊椎动物发生 严重神经系统疾病甚至死亡，对马养殖业发展和人类公共卫生安全构成严重威胁。近年来， 全球多地相继出现EEEV感染病例，为疫情防控敲响警钟。疫苗接种是预防该病的关键手段， 但目前尚无预防性疫苗获批上市。该文综述近年来EEEV疫苗的研究方向与进展，旨在为该 病毒疫苗研发及相关疫病防控提供参考。

关键词: 东方马脑炎病毒；人兽共患病；疫苗研发；研究进展