关键词: 犬细小病毒；感染机制；宿主免疫应答；病毒?宿主相互作用

Abstract: Canine parvovirus（CPV）is a pathogen that causes enteritis and myocarditis in dogs.Its pathogenic mechanism involves a complex interplay between the virus and the host immune system.This article focuses on the mechanisms of viral invasion and replication，as well as immune interactions，revealing the interaction between the VP2 capsid protein and host proteins，the multiple functions of NS1/NS2 proteins，and the regulatory mechanisms of virus on host cells along with its immune evasion strategies.Concurrently，the pathological changes resulting from an imbalance in the inflammatory response are analyzed，and the application progress of proteomics is briefly described. This study integrates existing findings to provide a reference for clarifying the pathogenic mechanism of CPV and developing novel diagnostic and therapeutic approaches.

Key words: Canine parvovirus；Infection mechanism；Host??immune response；Virus?host interaction