Abstract: Canine transmissible venereal tumor（CTVT）is a common directly transmissible round cell tumor in dogs. This report describes a case of CTVT in a 6?year?old intact male Golden Retriever. The dog was presented with dysuria，urine dribbling，and frequent licking of the genital area. Based on the mating history and local examination，a nodular proliferation with an irregular surface that bled easily on contact was identified at the distal glans penis. Urinary catheterization could be performed slowly，indicating that the local mass had caused urethral irritation or compression，but not complete obstruction. Complete blood count and serum biochemical revealed no obvious abnormalities. Histopathological examination showed diffuse proliferation of round tumor cells with prominent cytoplasmic vacuolation， distinct nucleoli， and frequent mitotic figures， confirming the diagnosis of CTVT. Considering the distal genital location of the lesion，the marked local irritation，and the associated urinary dysfunction，tumor excision combined with castration was performed，followed by postoperative intravenous vincristine chemotherapy（0.54–0.76 mg per treatment，once weekly for 4 weeks）. After treatment，the dog showed only mild lethargy. The surgical site healed well，urination returned to normal，and no local recurrence was observed during follow?up. This case suggests that，for genital CTVT with local functional involvement，individualized treatment should be planned based on a comprehensive assessment of lesion extent and local effects. For localized cases with marked local symptoms and a need for rapid reduction of tumor burden，surgery combined with postoperative vincristine chemotherapy may have practical clinical value.

Key words: Canine； Canine Transmissible Venereal Tumor； Histopathology； Vincristine； Individualized Treatment

摘要： 犬传染性性病肿瘤（Canine Transmissible Venereal Tumor，CTVT）是犬常见的可直接 传播性圆形细胞肿瘤。该文报道1例6岁未绝育雄性金毛寻回犬CTVT病例。患犬因排尿困 难、尿滴漏、频繁舔舐生殖器而就诊，结合交配史及局部检查，见龟头前段结节样增生、表面不 整、触碰易出血；导尿可缓慢通过，提示局部肿物已对尿道造成刺激或压迫，但尚未形成完全 性梗阻。血常规和血液生化检查未见明显异常。组织病理学显示肿瘤细胞呈圆形弥漫性增 生，胞质空泡明显，核仁清楚，可见较多有丝分裂象，最终确诊为CTVT。根据病灶位于生殖 器末端、局部刺激明显并伴排尿异常的特点，治疗上采用肿物切除联合去势术，并于术后给予 长春新碱静脉化疗（每次0.54－0.76 mg，每周1次，连续4周）。治疗后患犬仅出现轻度嗜睡， 术区愈合良好，排尿恢复正常，随访期内未见局部复发。该病例提示，对伴有局部功能受累的 生殖器型CTVT，应在综合评估病变范围和局部影响的基础上制定个体化治疗方案；对于局部 症状明显、需尽快减轻肿瘤负荷的病例，手术联合术后长春新碱化疗具有一定临床应用价值。

关键词: 犬；传染性性病肿瘤；组织病理学；长春新碱；个性化治疗