Thirty ? six wild Macaca Mulatta were anesthetized by intramuscular injection of Telazol 50 （a combination of tiletamine and zolazepam）at the dose of（5.79 ± 1.28）mg/kg. During the anesthesia，analgesia， sedation，muscle relaxation，respiration，heart rate，blood pressure，body temperature and blood oxygen saturation were monitored. The results showed that the induction period of Telazol 50 was（2.72±1.72）min，and the average induction effect was judged to be“excellent”. The body temperature was（38.74±0.46）℃，which was lower than the normal body temperature. Respiratory rate was（20.12 ± 0.15）beat/min，heart rate （143.96 ± 15.69）time/min and oxygen saturation（93.71±2.66）% at 5 to 30 min during anesthetic stage，all of which were slightly lower than those before anesthesia. The average anesthesia effect was determined as 4?5（moderate to surgical anesthesia），the duration of anesthesia maintenance（46.22±11.08）min，and the average analepsia effect was“fair”to“good”. The effect of Telazol 50 on wild Macaca Mulatta anesthesia（chemical restraint）was definite，but the recovery process was long.