关键词: C57BL/6小鼠；生长曲线；血液生理生化指标；脏器重量；脏器指数

Abstract: To determine the growth curve，blood physiological and biochemical parameters and main organ weights of C57BL/6 mice introduced and produced in our center，so as to provide basic reference data for the application of C57BL/6 mice. The body weight of 80 SPF C57BL/6 mice（equal male and female）aged 3－8 weeks was measured，and the growth curve was plotted. Twenty C57BL/6 mice（5 - and 10-week-old，equal male and female）were randomly selected for in vivo weighing. Following anesthesia，blood was collected via retro-orbital puncture for hematological and biochemical analyses，and major organs were dissected and weighed. Body weight increased with the age，with rapid growth at 3－5 weeks before gradually stabilizing. Significant differences（P<0.01 or P<0.05） were observed in certain hematological parameters，biochemical indices，organ weights，and organ coefficients between sexes within the same age group and between age groups within the same sex. The results of this study provided basic reference data for the application of C57BL/6 mice. It was found that week age and gender had certain effects on blood physiological and biochemical indexes，major organ weight and organ coefficient of C57BL/6 mice. Attention should be paid to the selection of week age and sex when using C57BL/6 mice.

Key words: C57BL/6 mice；Growth curve；Blood physiological and biochemical indexes；Organ weight；Organ coefficient